Polynucleotides are regenerative injectable treatments that repair, revitalise and hydrate the skin at a cellular level — a favourite for tired under-eyes, skin quality and the early signs of ageing.
Polynucleotides are purified chains of nucleotides — the building blocks of DNA — used in regenerative medicine to stimulate the skin's own repair processes. Rather than adding volume like a filler, they work within the skin: boosting cell turnover, improving elasticity, binding water for deep hydration and providing powerful antioxidant protection against the damage caused by UV light and everyday stress.
We use PLENHYAGE® XL, a leading medical-grade polynucleotide product, with two strengths tailored to the area being treated: a medium formulation designed for the delicate under-eye area, and a stronger formulation for the face, neck and décolleté.
A course of two treatments, four weeks apart, is advised for optimal results, with a maintenance session roughly every six months.
Numbing cream keeps the treatment comfortable. A series of small injections places the product exactly where it's needed; these create tiny bumps ("blebs") under the skin that settle within 24–48 hours, occasionally with a little bruising.
Because polynucleotides work by stimulating your skin's own regeneration, results build gradually: expect to see improvement from two to four weeks, continuing to develop over the following two to three months. They pair beautifully with microneedling and a ZO® Skin Health routine for a full skin-quality transformation.
Filler adds volume to reshape or plump an area. Polynucleotides don't add volume — they improve the quality of the skin itself: firmer, more elastic, better hydrated and healthier over time. Many clients combine the two for different goals.
A course of two treatments spaced four weeks apart is advised for best results, with a maintenance session roughly every six months to keep the benefits going.
Minimal. The small injection bumps settle within 24–48 hours and any bruising is usually mild and easy to cover. Most clients return to normal activities the same day.
Polynucleotides stimulate your skin's own repair, so results appear gradually — typically from two to four weeks after treatment, building over the following months as collagen and elastin improve.
Every treatment begins with a complimentary, no-obligation consultation at our Alderley Edge clinic.
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